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Log into your Roundcube mail interface using http://webmail.domain.com
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When you are successfully logged in, go to Settings.
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In the settings menu, select Filters, you create a new filter on the bottom of the filter.
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Click on Roundcube -> Create -> For Scope , choose all Messages with Actions -> Reply with Message
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Give the filter a name eg “Out of Office” and for message body, please type the message you want to send send on the out of office reply.
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To enable and save this filter, TICK on the Filter Enabled box. This will make the out of office reply enabled.
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After this is done press Save.
Webmail
How to configure Email Auto Responder in Roundcube for Plesk
Practical steps: How to configure Email Auto Responder in Roundcube for Plesk